Benzenepropanamide, N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-
N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-benzenepropanamide
CAS: 566914-00-9
Molecular Formula: C18H26N2O2
Benzenepropanamide, N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]- - Names and Identifiers
Benzenepropanamide, N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]- - Physico-chemical Properties
| Molecular Formula | C18H26N2O2 |
| Molar Mass | 302.41 |
| Solubility | Soluble in DMSO |
| Storage Condition | -20℃ |
| Use | TLR1 (compound 4a) is a low molecular weight, cell penetration Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimetic. TLR1 inhibits IL-1 receptor-mediated responses. |
| In vitro study | TLR1 inhibits IL-1β-induced phosphorylation of the mitogen-activated protein kinase p38 in EL4 thymoma cells and in freshly isolated murine lymphocytes in a concentration-dependent manner. |
| In vivo study | TLR1 interferes with the interactions between mouse MyD88 and IL-1RI at the TIR domains. TLR1 produces a significant attenuation of the IL-1β-induced fever response (200 mg/kg, i.p.). |
Benzenepropanamide, N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.307 ml | 16.534 ml | 33.068 ml |
| 5 mM | 0.661 ml | 3.307 ml | 6.614 ml |
| 10 mM | 0.331 ml | 1.653 ml | 3.307 ml |
| 5 mM | 0.066 ml | 0.331 ml | 0.661 ml |
Last Update：2024-01-02 23:10:35
Benzenepropanamide, N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]- - Reference Information
| biological activity | TLR1 (compound 4a) is a kind of low molecular weight, cells penetrate Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimetic. TLR1 inhibits IL-1 of receptor-mediated responses. |
Last Update：2024-04-09 21:01:54
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Product Name: N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-benzenepropanamide Visit Supplier Webpage Request for quotation
CAS: 566914-00-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 566914-00-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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